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Lysergol


NAME: LYSERGOL

CAS Number: 602-85-7

Chemical Name: (7-Methyl-4, 6, 6a, 7, 8, 9-hexahydro-indolo[4, 3-fg]quinolin-9-yl)-methanol

Molecular Weight: 254.33

Molecular Formula: C16H18N2O

Available Form: Powder

Grades Available: 40% & 95% by HPLC

Source

Ipomoea muricata synonyms I. turbinate, Calonyction muricata belongs to the family of the Convolvulaceae. It is a creeper and widely grows in all places. The plant is commonly known as morning glory. Flowers are purple or white up to 8 cm diameter. Fruits are pendulum shape capsules. Seeds are commonly known as “Kaladana” in trade and are being used as purgative in India and Pakistan1

Potential Uses

  • Lysergol has been used as hypotensive, psychotropic analgesic and uterus and intestine stimulating drug2
  • Recently invented the novel bio enhancing potential of lysergol, which acts as bioavailability facilitator for antibiotics and helps in transferring the antibiotics across the membrane for better efficacy on the target site3
  • Starting material for the synthesis of modern anti Parkinson drug “Cabergoline”4
  • As an main intermediate in the manufacture of ergoloid medicines (e.g., Nicergoline)
    Nicergoline: It is an ergoloid mesylate derivative used to enhance mental clarity, perception and concentration. Nicergoline, currently being used in the battle to treat senile dementia, has been found to improve mental agility through enhancing perception and vigilance, which improves oxygen stability and increases mental ability. Nicergoline has alpha-adrenolytic action which activates the brain's metabolism and improves arterial flow, lowers vascular resistance, improves the use of glucose and oxygen and it increases nerve growth in the aged brain.

PRODUCT SPECIFICATION

QUALITY CONTROL DEPARTMENT
Product Name LYSERGOL 95%
Botanical Name Ipomoea muricata
Plant part Seeds
Molecular formula C16H18N2O
Molecular weight 254.33
CAS Number 602-85-7
S. No. Parameters Specification Method
Physical
1 Description White to Off white color powder Visual
2 Identification To comply by HPLC KVN/QC/STP-IN/008
3 Loss on drying NMT 5.0% USP <731>
4 Residue on Ignition NMT 8.0% USP <281>
5 Tapped bulk density 0.30-0.80g/ml USP <616>
6 # 60 mesh NLT 95%w/w USP <786>
Sieve test (passes through)
Chemical
7 Assay By HPLC content of Lysergol NLT 95.0% w/w on dry basis KVN/QC/STP-IN/008
Others
8
Heavy Metals
Lead NMT 5.0ppm ICP-OES
Arsenic NMT 1.0ppm ICP-OES
Cadmium NMT 0.3ppm ICP-OES
Mercury NMT 0.1ppm ICP-OES
9 Residual solvents Should comply by ICH/USP USP <467>
Microbiological Profile
10
Total plate count NNMT 5000cfu/g USP <2021>
Yeast and molds count NMT 100cfu/g USP <2021>
Escherichia coli Absent /10g USP <2022>
Salmonella Absent /10g USP <2022>
Staphylococcus aureus Absent /10g USP <2022>
Pseudomonas aeruginosa Absent /10g USP <62>

We will provide the Spectral Data on Request